SARS-CoV-2 is spreading particularly fast in the Wet
The nasal cavity seems to play a much more important role in the progression of the disease, from COVID-19, as was previously thought. An American research team looked at how the Coronavirus SARS-CoV-2 spreading in the body and found that it replicated the fastest in the nasal cavity. There decides also whether it affects the lungs and the disease is so massively aggravated.
Researchers from the University of North Carolina mapped in the context of a current study, the propagation paths of SARS-CoV-2 within the respiratory tract. The Team was amazed that the Virus affects the nasal cavity and there quickly spreads. In the lower respiratory tract, the novel Coronavirus seems to multiply less well. This breakthrough could have a major impact on early intervention to prevent the Virus infects the lungs. The study was recently presented in the prestigious scientific journal “Cell”.
The nose was the first to be awarded a minor role
As the Coronavirus SARS-CoV-2 occurred for the first time at the end of the year 2019, the scientists believe that the Virus affects primarily the throat and the lungs. The nose was the first to be awarded a significant role. The current study revealed, however, that the nasal cavity plays a major role in the spread of the virus within the body. Here, you can multiply SARS-CoV-2 are particularly fast and here you decide, whether it affects the lower respiratory tract and the disease is massively aggravated. This could be one of the reasons why the disease may run in the course of Person-to-Person so different.
Can nasal rinses and Sprays to prevent severe infection?
“This is a groundbreaking study that revealed new and unexpected insights into the mechanisms of the progression and the Severity of the disease, according to a SARS-CoV-2 infection regulate,” explains Professor Ralph Baric, one of the study’s authors. “If the nose is to be seeded the dominant output, the lung infections, the widespread use of masks to protect the Nasal passages, as well as all the therapeutic strategies that reduce the Virus in the nose, such as nasal lavage or anti-viral nasal sprays, could be of benefit,” adds Professor of medicine Richard Boucher, another author of the study.
SARS-CoV-2 can replicate in certain cells faster
The research team tried in the study, a number of things to understand about the Virus better, among other things, what are the cells in the respiratory tract, it infects and how it causes the Affected lung inflammation, and how the Virus enters the lungs. The Team of different isolates of SARS-CoV-2 used to determine how efficiently the viruses cultured can infect fourth cells from different Parts of the human respiratory system.
The researchers are eye-catching pattern in a high infectivity of SARS-CoV-2 found in the cells lining the Nasal passages. In the cells of the pharynx, the bronchi and the lung was able to replicate the Virus, however, relatively slow. The results suggest that the Virus tends initially in the nasal cavity to firmly implant itself in the wall. But in some cases, the Virus is aspirated into the lungs, where it can cause more serious diseases, including a potentially fatal inflammation of the lungs,.
Why can spread SARS-CoV-2 in the nose quickly?
The Virus needs a specific Receptor in the cells to invade. This so-called ACE2-Rezepror, a Protein on the surface of certain cells is especially abundant in the cells lining the nasal cavity. In the lower respiratory tract come to ACE2 receptors also, but rarely, as the research work documented.
SARS-CoV-2 due to affects only two cell types in the respiratory
The researchers also found that SARS-CoV-2 infects only cells of the respiratory tract lining, so-called epithelial cells. In addition, the Coronavirus can penetrate into Pneumocytes. These are specialized cells in the lining in the lungs, the pulmonary vesicles (alveoli), and so the Transfer of inhaled oxygen into the bloodstream to help. Apart from these types of cells the SARS-CoV-2 seems to infect any other cells in the respiratory tract.
Luminous Corona Virus
During the study, the researchers developed also an opportunity to develop a fluorescent Version of SARS-CoV-2, making it easier in the body can be followed. This could also be for future studies to be useful. “These results, in which a novel and innovative methodology is used, open up new directions for future studies of SARS-CoV-2, which could guide therapeutic development and practices to reduce the Transmission and severity of COVID-19,” says James Kiley from the study team. (vb)