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High antibiotic prescription rates in low- and middle-income countries may indicate misuse

Inappropriate use of antibiotics is an important driver of antimicrobial resistance, yet the extent of antibiotic prescribing in outpatient primary care settings across low- and middle-income countries (LMICs) is unknown. A study published in PLOS Medicine by Giorgia Sulis and Madhukar Pai at McGill University, Montreal, Canada and colleagues found that approximately 50% of patients at primary care clinics in LMICs received at least one antibiotic, possibly suggesting widespread overprescribing.

To assess the magnitude and patterns of antibiotic prescribing in primary care settings across LMICs, the researchers systematically reviewed over 10,000 published studies, focusing on 48 cross-sectional studies in their final analyses. Using available data from individual studies, they calculated the proportion of patients who received an antibiotic prescription from a LMIC healthcare facility and the proportion of all drug prescriptions containing any antibiotic. While the researchers were able to quantify widespread prescribing of antibiotics in primary care settings, most analysed studies did not evaluate the appropriateness of prescriptions. The authors also conducted a subgroup analysis of 16 studies that reported details on prescriptions and found that 60% of antibiotics were commonly used drugs with a low potential for selecting resistance.

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