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Phenylalanine degrading probiotics are a more effective live biotherapeutic for phenylketonuria

Phenylalanine degrading enzymes-displayed probiotics are more effective live biotherapeutic for phenylketonuria

Research published recently in Science China Life Sciences led by Prof. Sheng Yang from the Key Laboratory of Synthetic Biology, Chinese Academy of Sciences and a collaborating company, developed an engineered probiotic with better efficacy in a mouse model of phenylketonuria.

Phenylketonuria, a disease resulting in the disability to degrade phenylalanine is an inborn error with a 1 in 10,000 morbidity rate on average around the world which leads to neurotoxicity. The prevailing and predominant treatment is restricting dietary intake supplemented with specifically designed medical foods.

Oral administration of recombinant phenylalanine ammonia lyase-expressing probiotics can degrade phenylalanine in the patient’s intestine into a non-toxic and urinary excreted metabolite, which has advantages of safety and high accessibility for phenylketonuria. The challenge is whether the activity of the engineered probiotic on phenylalanine is high enough to reduce the patient’s blood phenylalanine level below the safety line.

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